Clinically proven to visibly improve the look of aging skin, Needle-less® Growth Factor Serum features 5 bio-engineered peptides inspired by the skin’s natural renewal processes. This biotech-powered formula helps enhance the appearance of firmness, smooth texture, and reveal a more youthful-looking complexion.
Clinically shown to improve the look of firmness and texture in 8 weeks
Visibly smooths and firms the appearance of skin
Revitalizes the look of skin for a more youthful appearance
Inspired by the skin’s natural renewal signals to improve the look of elasticity
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Clinically proven to visibly improve the look of aging skin, Needle-less® Growth Factor Serum features 5 bio-engineered peptides inspired by the skin’s natural renewal processes. This biotech-powered formula helps enhance the appearance of firmness, smooth texture, and reveal a more youthful-looking complexion.
Clinically shown to improve the look of firmness and texture in 8 weeks
Visibly smooths and firms the appearance of skin
Revitalizes the look of skin for a more youthful appearance
Inspired by the skin’s natural renewal signals to improve the look of elasticity
Before and After 12 Weeks Of Use
When using the Needle-less® Growth Factor Serum as directed. Unedited and not retouched. Results may vary.
Discover Next-Gen Skincare, Backed by Biotech
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Discover Next-Gen Skincare, Backed by Biotech
4 Reasons You’ll Love Needle-less® Growth Factor Serum
Mimics the Skin's Natural Regenerative Signals
A blend of 5 bio-engineered growth factor peptides mimics your skin’s repair messengers, encouraging faster cell renewal without the use of human-derived ingredients.
Visibly Lifts & Firms
Clinically tested to deliver real results. 90% of participants noticed skin felt firmer, improved clarity & tone, and an improvement in overall appearance in just 12 weeks.*
Outperformed the Leading Growth Factor Serum at ¼ the price
In a 12-week IRB-approved, randomized, double-blinded, controlled clinical trial, our formula delivered 30% greater overall visible improvement, without the $295 price tag.
Repairs & Strengthens Skin Barrier
This serum features our CeraPep™ Technology, a proprietary blend of ceramides and peptides that restores the barrier’s essential lipids. So not only does this all-new formula lift and firm, but it’s proven to strengthen skin’s barrier after just one use.
Dr. Dayan on Needle-less® Growth Factor Serum:
“In this 12-week clinical study, participants were split into two groups—each applying a different topical treatment twice daily. Preliminary results showed visible improvements in wrinkles, texture, and firmness across both groups. One group used DRMTLGY's product, while the other used SkinMedica’s TNS Advanced+ Serum priced 4x more. However, the formula developed by DRMTLGY demonstrated notably superior results in skin texture and firmness.”
Dr. Dayan on Needle-less® Growth Factor Serum:
Dr. Steven H. Dayan
MD, FACSThe problem with most anti-aging serums is simple: they promise results but rarely prove they work. Many claim to smooth, firm, and lift—but where’s the evidence?
When we created Needle-less® Growth Factor Serum, we set out to do things differently. Instead of adding just another product to the lineup, we took a smarter approach—grounded in advanced technology and proven by real clinical testing.
In a 12-week, double-blind, IRB-approved clinical trial, Needle-less® Growth Factor Serum was tested head-to-head against SkinMedica’s TNS Advanced+ Serum, the industry’s best-known growth factor serum (sold at nearly 4x the price). The results spoke for themselves:
- Investigator-assessed improvements in skin texture and firmness were significantly higher for Needle-less® at both Week 8 and Week 12
- On the Global Aesthetic Improvement Scale (GAIS) at Week 12, Needle-less® Growth Factor Serum showed 30% greater overall improvement than the competitor
- It outperformed the leading growth factor serum in 73% of performance indicators
Directions
Apply 1-2 pumps to clean skin in the morning or evening. Can be used daily or as directed by a physician.
Ingredients
Ingredient Highlights: Sodium Hyaluronate, Palmitoyl Tripeptide-1, Oligopeptide-3, Oligopeptide-2, Oligopeptide-1, Hexapeptide-11, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Ceramide NP, Folic Acid, Phytosphingosine, Ceramide AP, Ceramide EOP, Chiretta (Swertia Chirata) Extract, Mushroom (Tremella Fuciformis) Sporocarp Extract
All Ingredients: Water/Aqua/Eau, Glycerin, Butylene Glycol, Pentylene Glycol, Maltodextrin, Coco-Caprylate/Caprate, Saccharide Isomerate, Sodium Hyaluronate, Palmitoyl Tripeptide-1, Oligopeptide-3, Oligopeptide-2, Oligopeptide-1, Hexapeptide-11, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Ceramide NP, Folic Acid, Phytosphingosine, Ceramide AP, Ceramide EOP, Triheptanoin, Chiretta (Swertia Chirata) Extract, Phenoxyethanol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, C9-12 Alkane, Polyurethane-100, Ethylhexylglycerin, Sodium Hydroxide, Lecithin, Trisodium Ethylenediamine Disuccinate, Acetyl Glutamine, 1,2-Hexanediol, Mushroom (Tremella Fuciformis) Sporocarp Extract, Hydrolyzed Hyaluronic Acid, Decyl Glucoside, Bacillus/Soybean Ferment Extract, Sodium Lauroyl Lactylate, Caprylyl Glycol, Carbomer, Polysorbate 20, Cholesterol, Xanthan Gum
DRMTLGY is dedicated to maintaining the accuracy of the ingredient lists on this website. However, because ingredients are subject to change, we cannot guarantee that these lists are error-free. For an accurate listing of ingredients in each product, please refer to your product packaging.
Skin Concerns
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Wrinkles
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Firmness
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Texture
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Dullness
Wrinkles
Firmness
Texture
Dullness
Skin Types
- Normal
- Oily
- Dry
- Combination
How to Layer Needle-less® Growth Factor Serum
Complete Your Regimen
Customer Reviews
This serum has quickly become a favorite for me. The DRMTLGY Needle-less Serum makes my skin look noticeably smoother and more plump, and it layers so nicely with the rest of my routine. My skin just looks healthier when I use it!
It’s pricey but good product!
5 stars
This product feels amazing and within weeks has shown effective on my boyfriend’s aging skin. He loves how it feels; luxurious.
It’s only been a couple weeks and I already notice a difference! My skin feels and looks healthy!
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