Meet the Needle-less® Duo
Meet the Needle-less® Duo
Upgrade your skincare with our most advanced anti-aging bundle, featuring Needle-less® Serum and Needle-less® Growth Factor Serum, designed to work together for visibly firmer, smoother, and plump skin.
Can I use both serums together?
Yes, they pair very well together. Use Needle-less® Serum first and then Needle-less® Growth Factor Serum
Can I use them with any form of retinoids?
Yes, you can use ANY product with both Needle-less® Serum and Needle-less®Growth Factor Serum.
Are they safe for sensitive skin?
Yes, the formula was tested to be safe and well tolerated, including on sensitive skin. As with any new skincare product, we recommend patch testing first to ensure your skin responds well.
SHOP NOW
60-Day Money Back Guarantee
Free U.S. Shipping Over $40
“[The] Growth Factor Serum by Drmtlgy is an innovative formula featuring a blend of clinically recognized peptides designed to stimulate collagen renewal, calm inflammation, and support skin barrier function,”
“Microneedling is on my skin care wishlist, as I have loads of dark spots from my acne journey I’ve been trying to fade for some time. This is one of the serums that has brought me the closest to my skin care goal—that is, smooth, soft skin with little evidence of my late-night TikTok scrolling.”
Get the best of both worlds
The Powerful Duo
Two advanced formulas powered by CeraPep™ Technology — a revolutionary blend of restorative peptides and ceramides that strengthen the skin barrier and lock in hydration.
Each works differently to target visible signs of aging, and together, they deliver a firmer, smoother, more youthful-looking complexion.
View Full Ingredient List
60-Day Money Back Guarantee
Free U.S. Shipping Over $40
Plump + Smooth
Needle-less® Serum
Our #1 bestselling serum that delivers instant hydration while visibly plumping fine lines and smoothing skin texture.
BENEFITS
Visibly plumps & smooths fine lines
Targets dullness & redness
Deeply hydrates & strengthens skin barrier
Powerful Ingredients
Copper Peptide Complex: Enhances skin renewal & firmness
Niacinamide: Brightens, evens skin tone, & reduces redness
Sodium Hyaluronate: Penetrates deeply, attracts water & hydrates
Lift + Firm
Needle-less® Growth Factor Serum
Our latest patent-pending biotechnology-driven formula that supports skin’s natural renewal process, helping to lift, hydrate, and improve the look of firmness.
BENEFITS
Softens the look of lines and wrinkles
Visibly lifts & firms sagging skin
Helps improve the look of elasticity
Powerful Ingredients
5X Vegan Bio-Growth Factor Complex: Mimics the skin’s most powerful regenerative signals
Swertia Chirata Extract: Promotes visible renewal & supports skin’s repair process
Palmitoyl Tripeptide-5: Smooths the look of deep wrinkles and improves resilience
ADD TO CART
–
Clinically Proven, Science-Backed Results
100%
found DRMTLGY's formulas gentle and non-irritating*
100%
said their skin appeared more youthful after using Needle-less® Growth Factor Serum for week 12*
94%
saw healthier-looking skin after using Needle-less® Serum for 6 weeks*
*Based on a 12-week double-blind IRB-approved clinical trial of 20 participants
**Based on a six-week independent consumer panel
"As a cosmetic chemist, I can tell you that growth factors are buzzing around the industry as THE solution for signs of aging. Growth factors, when they're reengineered with biotech like this and proven with clinical results, are absolutely worth having in your routine."
– Kenna Whitnell, Cosmetic Chemist
"Think of your skin like a house! ... When the builder and the renovator both do their jobs, the house isn't just strong, it looks refreshed and brand new. That's what this combo does for your skin."
– Gladys Chang
SHOP NOW
HOW TO LAYER
Both can be used 2X a day for best results
Reviews









Ships within 24 Hours Mon-Fri
FREE U.S. Shipping Over $40
60-Day Money Back Guarantee
Reviews
One-time purchase
GET 20% OFF TODAY
Auto-ship
GET 30% OFF FOREVER
1-month supply delivered every 1 month
FREE shipping
Pause or cancel anytime
60 days risk-free
Flexible delivery schedule
FREE SHIPPING
$138
In stock, ready to ship
Frequently Asked Questions
SHOP NOW
Can I use Needle-less® Serum with Needle-less® Growth Factor Serum?
Yes, they pair very well together. Use Needle-less® Serum first and then Needle-less® Growth Factor Serum.
Can I use any form of retinoid (retinol, tretinoin, etc) with Needle-less® Growth Factor Serum?
Yes, you can use ANY product with Needle-less® Growth Factor Serum.
Are the vegan growth factors used as effective as human growth factors?
This was one of the main reasons we conducted our clinical trial; we wanted to prove ours was as, or more effective. Our clinical test went up against a competitive product that uses human growth factors, and ours outperformed theirs by ~70%.
Is Needle-less® Growth Factor Serum safe for sensitive skin?
Yes, the formula was tested to be safe and well tolerated, including on sensitive skin. As with any new skincare product, we recommend patch testing first to ensure your skin responds well.