Needle-less® Growth Factor Serum

Biotech-powered, Firming Serum

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$69.00 USD $55.20
20% OFF
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1 fl oz
Full Size
Mini

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Clinically proven to visibly improve the look of aging skin, Needle-less® Growth Factor Serum features 5 bio-engineered peptides inspired by the skin’s natural renewal processes. This biotech-powered formula helps enhance the appearance of firmness, smooth texture, and reveal a more youthful-looking complexion.

  • Clinically shown to improve the look of firmness and texture in 8 weeks

  • Visibly smooths and firms the appearance of skin

  • Revitalizes the look of skin for a more youthful appearance

  • Inspired by the skin’s natural renewal signals to improve the look of elasticity

Clinically proven to visibly improve the look of aging skin, Needle-less® Growth Factor Serum features 5 bio-engineer...

Before and After 12 Weeks Of Use

When using the Needle-less® Growth Factor Serum as directed. Unedited and not retouched. Results may vary.

Discover Next-Gen Skincare, Backed by Biotech

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90%
of participants showed visible improvement by week 12*
73%
of performance indicators showed DRMTLGY outperformed SkinMedica's $295 TNS Advanced+ Serum*
30%
greater visible improvement than SkinMedica's $295 TNS Advanced+ Serum*
*Based on a 12 week double-blind IRB-approved clinical trial of 20 participants.

4 Reasons You’ll Love Needle-less® Growth Factor Serum

001

Mimics the Skin's Natural Regenerative Signals

A blend of 5 bio-engineered growth factor peptides mimics your skin’s repair messengers, encouraging faster cell renewal without the use of human-derived ingredients.

002

Visibly Lifts & Firms

Clinically tested to deliver real results. 90% of participants noticed skin felt firmer, improved clarity & tone, and an improvement in overall appearance in just 12 weeks.*

003

Outperformed the Leading Growth Factor Serum at ¼ the price

In a 12-week IRB-approved, randomized, double-blinded, controlled clinical trial, our formula delivered 30% greater overall visible improvement, without the $295 price tag.

004

Repairs & Strengthens Skin Barrier

This serum features our CeraPep™ Technology, a proprietary blend of ceramides and peptides that restores the barrier’s essential lipids. So not only does this all-new formula lift and firm, but it’s proven to strengthen skin’s barrier after just one use.

“In this 12-week clinical study, participants were split into two groups—each applying a different topical treatment twice daily. Preliminary results showed visible improvements in wrinkles, texture, and firmness across both groups. One group used DRMTLGY's product, while the other used SkinMedica’s TNS Advanced+ Serum priced 4x more. However, the formula developed by DRMTLGY demonstrated notably superior results in skin texture and firmness.”
Dr. Steven H. Dayan

Dr. Dayan on Needle-less® Growth Factor Serum:

The problem with most anti-aging serums is simple: they promise results but rarely prove they work. Many claim to smooth, firm, and lift—but where’s the evidence?

When we created Needle-less® Growth Factor Serum, we set out to do things differently. Instead of adding just another product to the lineup, we took a smarter approach—grounded in advanced technology and proven by real clinical testing.

In a 12-week, double-blind, IRB-approved clinical trial, Needle-less® Growth Factor Serum was tested head-to-head against SkinMedica’s TNS Advanced+ Serum, the industry’s best-known growth factor serum (sold at nearly 4x the price). The results spoke for themselves:

  • Investigator-assessed improvements in skin texture and firmness were significantly higher for Needle-less® at both Week 8 and Week 12
  • On the Global Aesthetic Improvement Scale (GAIS) at Week 12, Needle-less® Growth Factor Serum showed 30% greater overall improvement than the competitor
  • It outperformed the leading growth factor serum in 73% of performance indicators

 

In other words, this isn’t just another serum with empty promises. It’s clinically proven skincare technology that reframes how we approach aging—helping skin look visibly lifted and visibly renewed.

Directions

Apply 1-2 pumps to clean skin in the morning or evening. Can be used daily or as directed by a physician.

Ingredients

Ingredient Highlights: Sodium Hyaluronate, Palmitoyl Tripeptide-1, Oligopeptide-3, Oligopeptide-2, Oligopeptide-1, Hexapeptide-11, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Ceramide NP, Folic Acid, Phytosphingosine, Ceramide AP, Ceramide EOP, Chiretta (Swertia Chirata) Extract, Mushroom (Tremella Fuciformis) Sporocarp Extract

 

All Ingredients: Water/Aqua/Eau, Glycerin, Butylene Glycol, Pentylene Glycol, Maltodextrin, Coco-Caprylate/Caprate, Saccharide Isomerate, Sodium Hyaluronate, Palmitoyl Tripeptide-1, Oligopeptide-3, Oligopeptide-2, Oligopeptide-1, Hexapeptide-11, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Ceramide NP, Folic Acid, Phytosphingosine, Ceramide AP, Ceramide EOP, Triheptanoin, Chiretta (Swertia Chirata) Extract, Phenoxyethanol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, C9-12 Alkane, Polyurethane-100, Ethylhexylglycerin, Sodium Hydroxide, Lecithin, Trisodium Ethylenediamine Disuccinate, Acetyl Glutamine, 1,2-Hexanediol, Mushroom (Tremella Fuciformis) Sporocarp Extract, Hydrolyzed Hyaluronic Acid, Decyl Glucoside, Bacillus/Soybean Ferment Extract, Sodium Lauroyl Lactylate, Caprylyl Glycol, Carbomer, Polysorbate 20, Cholesterol, Xanthan Gum

 

DRMTLGY is dedicated to maintaining the accuracy of the ingredient lists on this website. However, because ingredients are subject to change, we cannot guarantee that these lists are error-free. For an accurate listing of ingredients in each product, please refer to your product packaging.

Skin Concerns

  • Wrinkles
  • Firmness
  • Texture
  • Dullness

Skin Types

  • Normal
  • Oily
  • Dry
  • Combination

How to Layer Needle-less® Growth Factor Serum

Complete Your Regimen

Customer Reviews

Based on 773 reviews
81%
(628)
10%
(80)
4%
(28)
2%
(16)
3%
(21)
R
Robin S.
Needleless growth, factor serum for the win! Pair with the needless serum!

In this instance, I opted to try the mini version of the serum. I am particularly fond of the serum, as it complements the needleless serum exceptionally well. I typically apply the needleless serum first, allowing it to fully dry before proceeding with the application of the needleless growth factor serum. I should have considered purchasing both serums together, as they offer a special discount when purchased in combination. Additionally, subscribing to their service provides an additional 25% discount, which is quite advantageous. Over the past year and a half, I have observed noticeable improvements in my skin’s appearance. I have consistently used both of these products and am thoroughly satisfied with their results.

M
Marisa Iannaccone
Age: 30 - 39
This is my holy grail, I swear it clears my face

This is my holy grail, I swear it clears my face up. I use it daily and am on my 4 or 5 bottle. Its on auto refill every few months.

T
Tyler F.
It works

Love the hydration it provides and noticeable results. Will definitely be in my everyday routine with winter coming.

T
Tawnya A.
Love this!

I do love the OG Needleless and the GF serum combo. I do wish the OG Needleless jad the thicker texture as the GF. I do understand they are different products serving different purposes. I just really like the thicker texture for application purposes.

K
Karen Wetzstein
Age: 40 - 55
Skin type: Sensitive
Love this stuff

Love the Needless growth factor serum, soaks in, no greasy or oily and I can' instantly notice less lines/wrinkles, I love this stuff. Try it, you will not be disappointed!

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