Needle-less Serum

Best Seller
Needle-less Serum
Needle-less Serum
Needle-less Serum
Needle-less Serum
Needle-less Serum
Needle-less Serum
Needle-less Serum

Needle-less Serum

1 fl oz
1 fl oz
2 fl oz

Free U.S. Shipping Over $40, and a risk-free guarantee!

If you don't love it, return it within 60 days for a full-refund - just contact us and we'll take care of you

Needle-less Serum is a twice-a-day serum that safely targets the appearance of fine lines around the mouth, eyes, and forehead, while also hydrating the skin to give a radiant glow! Our advanced formula helps with signs of aging by strengthening the skin’s moisture barrier, while improving the look of skin fullness and pore appearance. Now formulated with our proprietary Cerapep® Technology: a revolutionary blend of restorative peptides & ceramides.

  • Our best-selling product
  • Works with any other skin care product and regimen
  • Absorbs quickly and doesn't leave a greasy residue

Proven Results

Drmtlgy image
Drmtlgy image
Drmtlgy image
Needle-less Serum Before Needle-less Serum After

Before and After 60 Days Of Use

When used as directed. Unedited and not retouched. Results may vary.

This product is suggested for people looking to:

  • Target the appearance of fine lines around the mouth, forehead, and eyes
  • Promotes a youthful appearance
  • Improve appearance in skin’s smoothness

Why Needle-less Serum?

Treat yourself to our most popular anti-aging serum. We know that this isn’t a facelift in a bottle. However, we have combined a potent blend of multiple revolutionary active ingredients to give your skin what it needs.

It's gentle on the skin, non-greasy, non-comedogenic and is suitable for any skin care routine!


Key Facts

  • A potent anti-aging serum that helps to firm the skin as well as dramatically reduce fine lines and wrinkles resulting in firmer and brighter-looking skin.
  • Safely targets fine lines around the mouth, eyes, and forehead, improving the look of skin fullness, pore appearance, and smoothness.
  • Contains powerful anti-aging ingredients such as hyaluronic acid, niacinamide(vitamin B3), and proprietary Cerapep Technology featuring a revolutionary blend of restorative peptides & ceramides, that visibly firm and promote skin regeneration.
  • The Needle-less serum is suitable for all skin types including those with sensitive skin.

Peer Reviewed Articles

Cosmeceuticals and Cosmetic Practice, November 2013, Chapter 10
Journal of Cosmetic Dermatology, April 2004, Volume 3, Issue 2, pages 88-93
British Journal of Dermatology, September 2000, Volume 143, Issue 3, pages 524-531
Journal of Drugs in Dermatology, December 2015, Volume 15, 1 Supplement 2, pages s24-37
Journal of Drugs in Dermatology, September 2011, Volume 10, Issue 9, pages 990-1000
Journal of Cosmetic Dermatology, February 2019, Volume 18, Issue 1, pages 346-354
Journal of Cosmetic Dermatology, June 2007, Volume 6, Issue 2, pages 75-82

Suitable For These Skin Types



  • Apply 4 to 5 drops onto fingers and smooth over a slightly damp face. Avoid getting too close to the eyes.
  • Allow to absorb before applying additional products.
  • Can be used twice a day or as directed by a physician.


Ingredient Highlights

Niacinamide (Vitamin B3), Hyaluronic Acid (Sodium Hyaluronate), Methyl Glucoside Phosphate Proline Lysine Copper Complex, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Ceramide EOP, Ceramide NP, Palmitoyl Tripeptide-5, Ceramide AP, Sodium Chondroitin Sulfate, Glycosaminoglycans, Pea Extract, Glucosamine HCI, Panthenol (Provitamin B5), Bambusa Vulgaris Leaf/Stem Extract


All Ingredients

Water, Glycerin, Sodium Chondroitin Sulfate, Sodium Hyaluronate, Pisum Sativum (Pea) Extract, Bambusa Vulgaris Leaf/Stem Extract, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Ceramide EOP, Glucosamine HCl, Glycosaminoglycans, Ceramide NP, Palmitoyl Tripeptide-5, Ceramide AP, Phytosphingosine, Cholesterol, Niacinamide, Sodium Lauroyl Lactylate, Methylglucoside Phosphate, Copper Lysinate/Prolinate, Panthenol, Tocopheryl Acetate, Phenoxyethanol, Polysorbate 20, Ethylhexylglycerin, Disodium EDTA, Butylene Glycol, Carbomer, Xanthan Gum

Skin Types

This product is suitable for these skin types.

Normal skin: No or few imperfections, no severe sensitivity, barely visible pores, a radiant complexion

Sensitive skin: Reaction to common ingredients, redness, itching, dryness

Dry skin: Dull complexion, rough complexion, red patches, more prone to wrinkles, skin is itchy and flaky

Oily skin: Skin appears shiny, enlarged pores, more prone to acne

Combination skin: Oily skin in some areas and dry skin in others.

Customer Reviews

Based on 2722 reviews
Emily Jastrzembowski
Age: 30 - 39
Skin type: Sensitive
Can't get enough - second bottle

I LOVE the needle-less serum and can't get enough of it. I'm on my second bottle - the first one lasted me about 3-4 months using it twice a day- and that's with the unfortunate event where I lost a good amount when I knocked it over! This is a staple in my skincare lineup!

gretchen goldsmith
Age: 55+
Skin type: Combination
A must use product!

Needle-less Serum is amazing! I have been using DRMTLGY products for 18 month now and I see, & feel tremendous improvements in my face & neck areas. I could not be happier!! I am often hearing, by those females in my town whom I get newly acquainted with, "You'll understand how aging skin becomes bothersome, once you hit 50-55 years old, you're too young to know this now..." As 62 year old, these words hold great value! My baby sister is 8 years my junior and while we are out together, we are asked if we are twins (she does not use the DRMTLGY products)!!

Vivian Kage
Age: 55+
Skin type: Dry
Best Serum ever

Love, love, love this product! I’ve been using Needle-less serum for over 4 months and have seen such an improvement in my skins texture and reduction of fine lines! Using it twice a day is the key for me.

Pam marshall
Age: 30 - 39
Skin type: Normal
Great serum!

This leaves my skin feeling hydrated! The bottle lasted me about 8 months which is great!

Rae Valverde
Age: 55+
Skin type: Sensitive

I usually don’t believe before and after pics but these pics are accurate. I’ve been using needle-less serum for about a month and the lines around my mouth have almost disappeared. They really bothered me so although it’s a little pricey, I will buy again.👍🏻

Frequently Asked Questions

Needle-less serum should be applied to clean damp skin. Follow with your moisturizer and sunscreen.

Yes, the Needle-less serum is formulated for all skin types.

The Needle-less serum is oil-free and noncomedogenic.

The Needle-less serum does not replace your moisturizer. It works best with an additional moisturizer layered on top. Without an occlusive layer, it can dry out the skin out.

Yes, absolutely. Needle-less serum can be applied day and/or night.

This product is manufactured and shipped in Los Angeles, CA.