2 oz Needle-less Serum

Firming Plumping Serum

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$119.00
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2 fl oz

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1 fl oz
2 fl oz

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If you don't love it, return it within 60 days for a full-refund - just contact us and we'll take care of you

DOUBLE THE SIZE! Experience visibly lifted, firmer, and deeply hydrated skin—no injections needed. This multitasking powerhouse serum blends our proprietary Cerapep™ Technology with targeted peptides, ceramides, and sodium hyaluronate to visibly smooth wrinkles, calm sensitivity, and reinforce your skin’s natural barrier. The perfect swap to simplify your complicated routine for one serum that delivers visible youthful results.

  • Visibly smooths fine lines and wrinkles
  • Firms and lifts the appearance of sagging skin
  • Energizes dull texture and enhances elasticity
  • Reduces redness, evens tone, and soothes sensitivity
DOUBLE THE SIZE! Experience visibly lifted, firmer, and deeply hydrated skin—no injections needed. This multitasking ...

4 Reasons Everyone Loves Needle-less Serum

1. Cosmo’s “Best Peptide Serum”

This serum works. But don't take our word for it—Cosmopolitan named it the "Best Peptide Serum" in 2023.

2. Dramatic Anti-aging Results You Can See

This active-packed serum is loaded with anti-aging superstars like Hyaluronic Acid, Niacinamide, and our proprietary Cerapep® Technology: a revolutionary blend of restorative peptides & ceramides.

3. Visibly Diminishes Fine Lines

Enriched with potent actives clinically proven to visibly improve the look of fine lines and wrinkles around the mouth, eyes, and forehead.

4. Brighten the Look of Pigmentation

Niacinamide strengthens the skin’s moisture barrier, while improving the look of pigmentation and pore appearance.

Proven Results

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Drmtlgy image
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Needle-less Serum Before Needle-less Serum After

Before and After 60 Days Of Use

When used as directed. Unedited and not retouched. Results may vary.

Get our #1 best selling product at TWICE THE SIZE!

As we age, our skin’s extracellular matrix begins to weaken—leading to loss of firmness, deeper creases, and uneven texture. Daily environmental stressors and harsh products can also compromise the skin barrier, leaving it more prone to sensitivity, redness, and dryness. Needle-less Serum was engineered to tackle all of these concerns in one powerhouse solution.

 

Our signature Cerapep™ Technology blends three skin-identical ceramides with a targeted peptide complex to replenish essential lipids and signal your skin to rebuild its structural integrity. This dual approach not only visibly lifts and firms, but also fortifies the barrier against future moisture loss and irritation. To further calm and balance, we’ve added niacinamide, a gentle vitamin B3 derivative known for reducing redness, refining pores, and regulating oil levels.

 

Hydration is key to younger-looking skin. Sodium hyaluronate, the salt form of hyaluronic acid with a smaller molecular weight, acts like a moisture magnet—holding up to 1,000× its weight in water—to plump out fine lines and refine texture. Meanwhile, pea extract and copper peptides support your skin’s own repair processes for improved elasticity and an even tone.

 

Whether you want to prolong your injectable results or prefer a non-invasive alternative, Needle-less Serum integrates seamlessly into any routine.

Directions

  • Apply 4 to 5 drops onto fingers and smooth over a slightly damp face. Avoid getting too close to the eyes.
  • Allow to absorb before applying additional products.
  • Can be used twice a day or as directed by a physician.

Ingredients

Ingredient Highlights

Niacinamide (Vitamin B3), Hyaluronic Acid (Sodium Hyaluronate), Methyl Glucoside Phosphate Proline Lysine Copper Complex, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Ceramide EOP, Ceramide NP, Palmitoyl Tripeptide-5, Ceramide AP, Sodium Chondroitin Sulfate, Glycosaminoglycans, Pea Extract, Glucosamine HCI, Panthenol (Provitamin B5), Bambusa Vulgaris Leaf/Stem Extract

 

All Ingredients

Water, Glycerin, Sodium Chondroitin Sulfate, Sodium Hyaluronate, Pisum Sativum (Pea) Extract, Bambusa Vulgaris Leaf/Stem Extract, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Ceramide EOP, Glucosamine HCl, Glycosaminoglycans, Ceramide NP, Palmitoyl Tripeptide-5, Ceramide AP, Phytosphingosine, Cholesterol, Niacinamide, Sodium Lauroyl Lactylate, Methylglucoside Phosphate, Copper Lysinate/Prolinate, Panthenol, Tocopheryl Acetate, Phenoxyethanol, Polysorbate 20, Ethylhexylglycerin, Disodium EDTA, Butylene Glycol, Carbomer, Xanthan Gum

Skin Concerns

  • Redness
  • Firmness
  • Wrinkles
  • Dryness
  • Post Procedure

Skin Types

  • Normal
  • Dry
  • Combination
  • Oily

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Customer Reviews

Based on 4120 reviews
92%
(3796)
6%
(231)
1%
(44)
1%
(25)
1%
(24)
K
Kathy Pierce
No more commas around my lips

I thought Needless-less Serum would be worth a try and it was!!! Sold after one night!! You will see results!

S
Sue
Age: 40 - 55
Skin type: Normal
Calming feeling

Love it for post peeling treatments

B
BTF
Age: 55+
Skin type: Normal
Irreplaceable

For nearly two weeks (crazy summer schedule), I didn’t have my Needle-less Serum. My skin missed absorbing the quality, nourishing ingredients and I didn’t “feel right” until I was able to include it in my routine again. I have a bunch of potions under my sink, but there’s no substitute for this one.

B
Barbara Moss
Age: 55+
Skin type: Combination
Excellent results!

I love all of the DRMTLGY products I use. I especially love the needleless serum, which I use morning and night every day. I am 77 years old and honestly do look younger, thanks to these wonderful products.

R
Rianne Vitek
Age: 40 - 55
Skin type: Sensitive
No gray areas here...

It's black & white when it comes to Needle-less Serum - it's a staple in my household. Lightweight, great even on sensitive skin... It certainly is my secret, well, no secret now, to younger looking skin!

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